Enter your medication into the WebMD interaction checker In particular, make sure that you discuss if you are using any of the following before taking buspirone. It is best to avoid alcohol when taking buspirone.
Brand names
- And having more medication in your system can increase the risk of side effects.
- It also comes as an oral capsule, but this article doesn’t cover that form.
- Subsequent dose adjustment of either drug should be based on clinical assessment.
- The safety and effectiveness of buspirone were evaluated in two placebo-controlled 6 week trialsinvolving a total of 559 pediatric patients (ranging from 6 to 17 years of age) with GAD.
- Buspirone is commonly used to treat anxiety disorders.
The typical starting dosage of buspirone oral tablet for anxiety is 15 mg daily. Other medications used to treat anxiety include beta blockers (such as propranolol), antidepressants (such as Lexapro), and benzodiazepines (such as Xanax). Other medications can also be effective in the treatment of anxiety disorders. Other treatments for anxiety may include benzodiazepines, SSRIs, or therapy such as cognitive behavioral therapy (CBT). Buspirone is from the azapirone class of medications, which includes other anxiolytic (anti-anxiety) and antipsychotic medications.
Your doctor will explain how you should take the buspirone oral tablet. They may suggest a treatment to manage your symptoms and can determine whether you should keep taking buspirone. Mild side effects of many drugs may go away within a few days to a couple of weeks. Buspirone oral tablet is used to help relieve anxiety. Buspirone oral tablet is used in adults to treat generalized anxiety disorder (commonly referred to as anxiety). A guide to therapy, medications, and techniques for managing anxiety
Plus, the doses needed to possibly make it more effective would also increase the drug’s side effects, limiting its use. For instance, one review of studies involving medication-based anxiety treatments noted that buspirone had not demonstrated effectiveness for social anxiety disorder. After multiple-dose administration of buspirone to patients with hepatic impairment, steady-state AUCof buspirone increased 13-fold compared with healthy subjects (see PRECAUTIONS). Buspirone hydrochloride tablets are contraindicated in patients hypersensitive to buspironehydrochloride. There were no significant differences betweenbuspirone and placebo with regard to the symptoms of GAD following doses recommended for thetreatment of GAD in adults. The syndrome of withdrawal from sedative/hypnotic/anxiolytic drugs can appear as any combination ofirritability, anxiety, agitation, insomnia, tremor, abdominal cramps, muscle cramps, vomiting, sweating,flu-like symptoms without fever, and occasionally, even as seizures.
What Are Warnings and Precautions for Buspirone?
Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are dizzy or are not alert. Ask your healthcare professional how you should dispose of any medicine you do not use. Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. The amount of medicine that you take depends on the strength of the medicine.
What Is Buspar?
If a patient has been titrated to a stable dosage on buspirone, a dose adjustment of buspirone may be necessary to avoid adverse events attributable to buspirone or diminished anxiolytic activity. In a study in healthy volunteers, coadministration of buspirone (30 mg as a single dose) with rifampin (600 mg/day for 5 days) decreased the plasma concentrations (83.7% decrease in Cmax; 89.6% decrease in AUC) and pharmacodynamic effects of buspirone. With 5 mg b.i.d. doses of buspirone, slight increases in AUC were observed for nefazodone (23%) and its metabolites hydroxynefazodone (HO-NEF) (17%) and meta-chlorophenylpiperazine (9%). In a study in healthy volunteers, coadministration of buspirone (10 mg as a single dose) with itraconazole (200 mg/day for 4 days) increased plasma buspirone concentrations (13-fold increase in Cmax Buspirone effects and 19-fold increase in AUC).
In case of emergency/overdose
In a study in healthy volunteers, coadministration of buspirone (10 mg as a single dose) with grapefruit juice (200 mL double-strength t.i.d. for 2 days) increased plasma buspirone concentrations (4.3-fold increase in Cmax; 9.2-fold increase in AUC). Subsequent dose adjustment of either drug should be based on clinical assessment. These pharmacokinetic interactions were accompanied by an increased incidence of side effects attributable to buspirone. In a study in healthy volunteers, coadministration of buspirone (10 mg as a single dose) with erythromycin (1.5 g/day for 4 days) increased plasma buspirone concentrations (5-fold increase in Cmax and 6-fold increase in AUC). Our Buspar Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.
Pregnancy
There are also medications that can affect how BuSpar is metabolized in the body, which can impact the effectiveness of your medication. For example, if you take buspirone along with amonoamine oxidase inhibitors (MAOIs), you may experience increased blood pressure. BuSpar can potentially interact with numerous medications. If the liver is not functioning normally, there may be increased concentrations of buspirone in the blood. In cases of hypersensitivity, your prescribing doctor will discontinue the medication treatment.
Buspirone tablet brand-name versions
The brand name for this medication is BuSpar®. You may report side effects to the FDA at FDA-1088. If you notice any other effects, check with your healthcare professional.
- Call your doctor if you think you’ve taken too much buspirone.
- In vitro preclinical studies have shownthat buspirone has a high affinity for serotonin (5-HT1A) receptors.
- You should always take buspirone with food or without food, so you get the same amount of medicine each time.
- When taken with buspirone, rifampin can lower the amount of buspirone in your body.
- Medications that affect liver enzymes may increase or decrease concentrations of buspirone in the blood, which can lead to more side effects or decreased effectiveness.
- Buspirone is used to treat anxiety disorders or in the short-term treatment of symptoms of anxiety.
If the two drugs are to be used in combination, the dosage of buspirone may need adjusting to maintain anxiolytic effect. If the two drugs are to be used in combination, a low dose of buspirone (e.g., 2.5 mg q.d.) is recommended. If the two drugs are to be used in combination, a low dose of buspirone (e.g., 2.5 mg b.i.d.) is recommended. Because the effects of concomitant administration of buspirone with most other psychotropic drugs have not been studied, the concomitant use of buspirone with other CNS-active drugs should be approached with caution.
Clinical Pharmacology for Buspar
RxList does not provide medical advice, diagnosis or treatment. The effects of race on the pharmacokinetics of buspirone have not been studied. After single or multiple doses in adults, no significant differences in buspirone pharmacokinetics (AUCand Cmax) were observed between elderly and younger subjects or between men and women. Theaverage elimination half-life of unchanged buspirone after single doses of 10 mg to 40 mg is about 2 to3 hours. In a single-dose study using 14C-labeled buspirone, 29% to 63% of the dose was excreted in the urinewithin 24 hours, primarily as metabolites; fecal excretion accounted for 18% to 38% of the dose.
BuSpar Uses
However, it is not known whetherthese drugs cause similar effects on plasma levels of free buspirone in vivo, or whether such changes,if they do occur, cause clinically significant differences in treatment outcome. The effects of food upon the bioavailability of buspirone hydrochloride tablets have been studied ineight subjects. Therefore, the administration of buspirone hydrochloride tablets to patients with severehepatic or renal impairment cannot be recommended (see CLINICAL PHARMACOLOGY). During your treatment with buspirone hydrochloride tablets, avoid drinking large amounts of grapefruitjuice. Because buspirone hydrochloride tablets have no established antipsychotic activity, it should not beemployed in lieu of appropriate antipsychotic treatment.
Buspirone hydrochloride tablets are indicated for the management of anxiety disorders or the short-termrelief of the symptoms of anxiety. Each buspirone hydrochloride tablet intended for oral administration contains 5 mg or 10 mg or 15 mg or 30 mg buspirone hydrochloride (equivalent to 4.6 mg, 9.1 mg, 13.7 mg, and 27.4 mg of buspirone free base, respectively). Learn more about some of the side effects that buspirone oral tablet may cause. Clinical trials of buspirone didn’t report any differences in the type of side effects based on the drug’s strength or prescribed dosage. It’s possible to have more side effects during the first week of buspirone treatment than after you’ve taken the drug for a few weeks.
BuSpar Medication Interactions
In aradiolabeled study, unchanged buspirone in the plasma accounted for only about 1% of the radioactivityin the plasma. Buspirone has no significantaffinity for benzodiazepine receptors and does not affect GABA binding in vitro or in vivo when testedin preclinical models. Buspirone differs from typical benzodiazepineanxiolytics in that it does not exert anticonvulsant or muscle relaxant effects.
If you develop a side effect while taking buspirone and want to tell the FDA about it, visit MedWatch or call 800-FDA-1088. For more information, you can refer to buspirone’s prescribing information. However, if the side effects last longer than that, bother you, or become severe, be sure to talk with your doctor or pharmacist.
What you’ll pay for buspirone may depend on several things, such as your treatment plan and the pharmacy you use. This can cause your body to process drugs more slowly. If it’s not working well, the amount of buspirone in your body can increase to dangerous levels. If they’re not working well, the amount of buspirone in your body can increase to dangerous levels. Grapefruit can increase the amount of buspirone in your body. During your treatment with buspirone, avoid drinking large amounts of grapefruit juice or eating large amounts of grapefruit.
